The fallout from Detroit's bankruptcy filing has investors - and even ratings agencies - questioning the validity of the bond rating system.
Now investors need to know if it can be fixed in a way that actually helps those investing in general obligation (GO) bonds.
In June, Detroit Emergency Manager Kevyn Orr sent the financial equivalent of a nuclear blast through the muni bond markets when he stated that holders of Detroit's GO bonds - whose holdings total roughly $600 million - will be lumped together with other unsecured creditors who collectively account for $11 billion in city obligations.
Historically, GO bonds were seen as the safest form of municipal debt. That's because historically municipalities would raise taxes, cut services - do anything - rather than force losses on bondholders.
"The bottom line is, Orr said that these bonds are unsecured, which potentially forces a loss on these investments," explains Money Morning Chief Investment Strategist Keith Fitz-Gerald. "If that's the case, then here we go: those formerly secured debts are in fact no safer than junk bonds. Which means, all of a sudden, in the blink of an eye, all the ratings on municipalities everywhere are suspect."
Primero Mining Corp. (Primero) is a precious metals producer with operations in Mexico. The Company is focused on precious metals assets in the Americas through acquiring, exploring, developing and operating mineral resource properties. As of December 31, 2011, Primero had one producing property, the San Dimas Mine, located in Mexico�� San Dimas district, on the border of Durango and Sinaloa states, and one exploration property, Ventanas, located in Durango state, Mexico. The San Dimas Mine consists of three underground gold and silver mining operations at Tayoltita, San Antonio (Central Block) and Santa Rita. In 2011, the San Dimas Mine produced 79,564 ounces of gold and 4.6 million ounces of silver. Primero also holds 28 mining concessions (3,470.4 hectares) at Mala Noche-Ventanas-San Cayetano (the Ventanas Project). Primero has three active, wholly owned subsidiaries include Primero Empresa Minera, S.A. de C.V., Silver Trading (Barbados) Ltd. and Primero Mining Luxembourg s.a r.l.
Advisors' Opinion: - [By Dan Caplinger]
Dan also highlights a new agreement with Brazil's Vale (NYSE: VALE ) as an example of a new partner streaming agreement that features a focus on gold. Can Silver Wheaton continue to profit from future agreements with partners such as Barrick Gold (NYSE: ABX ) , Primaro Mining (NYSE: PPP ) , and Hudbay Minerals (NYSE: HBM ) ?
- [By MONEYMORNING]
As well, Primero Mining (NYSE: PPP) bought Brigus Gold Corp (USA)(NYSE: BRD) for $220 million, and Asanko Gold (NYSEMKT: AKG) is acquiring PMI Gold Corporation (TSE: PMV).
Top 10 Safest Companies To Own For 2014: Nuveen Tax-Advantaged Total Return Strategy Fund (JTA)
Nuveen Tax-Advantaged Total Return Strategy Fund operates as a diversified and closed-end management investment company. The fund primarily invests in dividend-paying common stocks. It also invests in senior loans, U.S corporate bonds, notes and debentures, convertible debt securities, as well as high yield debt securities. Its portfolio primarily includes investments in oil and gas, diversified telecommunication, services, diversified financial services, tobacco, insurance, aerospace and defense, metals and mining, commercial banks, electric utilities, thrifts and mortagage finance, and paper and forest product sectors. Nuveen Tax-Advantaged Total Return Strategy Fund was organized in 2003 and is based in Chicago, Illinois.
Advisors' Opinion: - [By Dividends4Life]
According to a Gabelli Funds report, managed distribution policies offer several advantages, including:1. Lower difference between the fund�� market price and its NAV per share.2. Provides support during periods when the stock market is in a decline.3. Provides a measurable performance target for the investment adviser.Below are several high-yield funds from CEFA that have a managed distribution policy (yields as of December 16):Aberdeen Australia Eqty (IAF)- Distribution Yield: 10.4%- Income Yield: 3.46%Bexil Advisers LLC� (DNI)- Distribution Yield: 11.1%- Income Yield: 3.56%BlackRock En Capital&Inc (CII)- Distribution Yield: 8.78%- Income Yield: 2.34%Cornerstone Strat Value (CLM)- Distribution Yield: 18.77%- Income Yield: 1.83%Cornerstone Total Return (CRF)- Distribution Yield: 19.10%- Income Yield: 0.85%Delaware Inv Div & Inc (DDF)- Distribution Yield: 6.70%- Income Yield: 5.26%Gabelli Equity Trust (GAB)- Distribution Yield: 7.58%- Income Yield: 1.54%Gabelli Utility Trust (GUT)- Distribution Yield: 9.45%- Income Yield: 2.84%MFS Special Value Trust (MFV)- Distribution Yield: 9.60%- Income Yield: 5.73%Nuveen Tx-Adv TR Strat (JTA)- Distribution Yield: 6.70%- Income Yield: 3.12%TCW Strategic Income (TSI)- Distribution Yield: 10.54%- Income Yield: 7.88%Zweig Total Return (ZTR)- Distribution Yield: 7.27%- Income Yield: 1.95%As noted in the Gabelli report, a managed distribution policy may create confusion regarding the true current yield since the reported yield includes the return of capital portion. You can see the disparity above between the income yield and the distribution (reported) yield.If you are looking for a sustainable and growing dividend, you may want to consider some blue-chip dividend stocks such as these with a Free Cash Flow Payout less than 50%, 50+ years of consecutive dividend increases and a 2%+ yield:3M Co. (MMM) is a diversified global company provides enhanced product functionality in electronics, health care, industrial, consumer
Top 10 Safest Companies To Own For 2014: Abraxas Petroleum Corp (AXAS)
Abraxas Petroleum Corporation is an independent energy company primarily engaged in the acquisition, exploitation, development and production of oil and gas in the United States and Canada. As of December 31, 2011, the Company�� estimated net proved reserves were 29.0 million barrels of oil equivalent (MMBoe), (including reserves attributable to its 34.7% equity interest in the proved reserves of Blue Eagle), of which 53% were classified as proved developed, 54% were oil and natural gas liquids (NGL��) and 94% by PV-10 were operated. Its daily net production during the year ended December 31, 2011, was 3,484 barrels of oil equivalent per day, of which 45% was oil or liquids. Its oil and gas assets are located in four operating regions in the United States, the Rocky Mountain, Mid-Continent, Permian Basin and onshore Gulf Coast, and in the province of Alberta, Canada.
The Company�� properties in the Rocky Mountain region are located in the Williston Basin of North Dakota and Montana and in the Green River, Powder River and Unita Basins of Wyoming and Utah. In this region, its wells produce oil and gas from various reservoirs, including the Niobrara, Turner, Bakken and Three Forks formations. Well depths range from 7,000 feet down to 14,000 feet. The Company�� properties in the Mid-Continent region are primarily located in the Arkoma Basin and principally produce gas from the Hartshorne coals at 3,000 feet. Its properties in the Permian Basin region are primarily located in two sub-basins, the Delaware Basin and the Eastern Shelf. In the Delaware Basin, its wells are located in Pecos, Reeves, and Ward Counties, Texas and produce oil and gas from multiple stacked formations from the Bell Canyon at 5,000 feet down to the Ellenburger at 16,000 feet.
In the Eastern Shelf, its wells are principally located in Coke, Scurry, Midland, Mitchell and Nolan Counties, Texas and produce oil and gas from the Strawn Reef formation at 5,000 to 7,500 feet and oil from the shallower Clea! rfork formation at depths ranging from 2,300 to 3,300 feet. The Company�� properties in the onshore Gulf Coast region are located along the Edwards trend in DeWitt and Lavaca Counties, Texas and in the Portilla field in San Patricio County, Texas. In the Edwards trend, its wells produce gas from the Edwards formation at a depth of 14,000 feet and in the Portilla field, its wells produce oil and gas from the Frio sands and the deeper Vicksburg from depths of approximately 7,000 to 9,000 feet. In addition, the Company also owns a 34.7% equity interest in a joint venture targeting the Eagle Ford in South Texas. Its properties in the province of Alberta, Canada are located in the Pekisko fairway and the Nordegg/Tomahawk area of Central Alberta.
As of December 31, 2011, the Company leased approximately 20,835 net acres, primarily in counties located on the Nesson Anticline and in areas west, including Rough Rider and Lewis & Clark in North Dakota and in Sheridan County, Montana, which are prospective for the Bakken and Three Forks formations. During the year ended December 31, 2011, the Company drilled two operated wells and participated in an additional 19 gross (1.0 net) non-operated wells. In July 2011, Abraxas purchased a used Oilwell 2000 horsepower diesel electric drilling rig. In August 2010, the Company formed a joint venture, Blue Eagle, with Rock Oil to develop its acreage in the Eagle Ford Shale play. As of December 31, 2011, the Company owned a 34.7% interest in Blue Eagle. During 2011, Blue Eagle drilled, completed or participated in three gross (2.4 net) wells and added approximately 3,800 net acres to its holdings, principally in McMullen County, Texas.
As of December 31, 2011, the Company leased a total of approximately 20,720 gross (17,800 net) acres in the southern Powder River Basin, of which 17,800 gross (15,700 net) acres were located in the Brooks Draw field of Converse and Niobrara Counties, Wyoming. In addition, it owns approximately 2,100 net acres in sout! hern Camp! bell County, Wyoming which are held by production and are near the Crossbow field operated by EOG Resources, Inc. and other recent horizontal activity. As of December 31, 2011, the Company leased 6,880 net acres in western Alberta. In 2011, it drilled or completed six gross (6 net) wells in the Twining area. In the emerging southern Alberta Basin Bakken play of Toole and Glacier Counties, Montana, the Company leased approximately 10,000 gross/net acres under long-term leases or direct mineral ownership. As of December 31, 2011, it leased approximately 5,600 gross/net acres in Nolan County, Texas. In 2011, the Company drilled three wells in the Spires Ranch offsetting the prolific Nena Lucia field.
Advisors' Opinion: - [By Monica Gerson]
Abraxas Petroleum (NASDAQ: AXAS) is estimated to post its Q4 earnings at $0.04 per share on revenue of $23.05 million.
Broadwind Energy (NASDAQ: BWEN) is projected to post a Q4 loss at $0.19 per share on revenue of $56.54 million.
- [By Lisa Levin] Related IIN Morning Market Movers Morning Market Losers Related AXAS Abraxas Petroleum Corp. (AXAS) in Focus: Stock Moves 6.4% Higher - Tale of the Tape Will Noble Energy Disappoint This Quarter? - Analyst Blog
Intricon (NASDAQ: IIN) shares gained 33.98% to touch a new 52-week high of $6.23 after the company reported Q1 results.
- [By Monica Gerson] Related AMKR Stocks to Watch for September 12, 2013 Seven Dividend-Paying Tech Stocks Analysts Are Bullish On Related AXAS EXCO Resources to Offer Senior Notes - Analyst Blog Abraxas (AXAS) Shares March Higher, Can It Continue? - Tale of the Tape
Amkor Technology (NASDAQ: AMKR) shares gained 1.63% to touch a new 52-week high of $7.46. Amkor Technology's PEG ratio is 0.94.
- [By Ben Levisohn]
Penn Virginia has gained 6.9% to $7.15 at 11:56 p.m. today, while Sanchez Energy (SN) has advanced 5.2% to $29.10, Abraxas Petroleum (AXAS) has risen 2.4% to $2.97 and Gulfport Energy (GPOR) is up 1.3% at $67.31.
Top 10 Safest Companies To Own For 2014: Flagstar Bancorp Inc (FBC)
Flagstar Bancorp, Inc. incorporated on October 28, 1993, is a savings and loan holding company. The Company�� business is primarily conducted through its principal subsidiary, Flagstar Bank, FSB (the Bank), a federally chartered stock savings bank. At December 31, 2012, its total assets were $ $14.1 billion. The Bank�� wholly owned subsidiary is Flagstar Capital Markets Corporation (FCMC). The Company operates in two segments: Community Banking and Mortgage Banking. The Community Banking segment offers a line of financial products and services to individuals, small and middle market businesses, and mortgage lenders. Its Mortgage Banking segment originates, acquires, sells and services residential first mortgage loans on one-to-four family residences. The Bank�� Other segment include corporate treasury, tax benefits not assigned to specific operating segments, and miscellaneous other expenses of a corporate nature.
Community Banking
Community Banking segment includes Branch Banking, Commercial and Business Banking, Government Banking, and Warehouse Lending. Community Banking segment originates loans and deposits to consumer, business and mortgage lending customers through its Branch Banking, Business and Commercial Banking, Government Banking, and Warehouse Lending groups. Products offered include checking accounts, savings accounts, money market accounts, certificates of deposit, consumer loans, commercial loans and warehouse lines of credit. Other financial services available to consumer and commercial customers include lines of credit, revolving credit, customized treasury management solutions, equipment leasing, inventory and accounts receivable lending and capital markets services such as interest rate risk protection products. At December 31, 2012, Branch Banking included 111 banking centers located throughout Michigan. As of December 31, 2012, the commercial loans held-for-investment totaled $0.7 billion, and consisted of commercial real estate, commercial and in! dustrial and commercial lease financing. At December 31, 2012, its commercial real estate loans held-for-investment totaled $640.3 million.
Commercial and industrial held-for-investment loan facilities include lines of credit to its small or middle market businesses for use in normal business operations to finance working capital needs, equipment purchases and expansion projects. At December 31, 2012 its commercial and industrial held-for-investment loans totaled $90.6 million. Its commercial lease financing held-for-investment loan portfolio is comprised of equipment leased to customers in a direct financing lease. At December 31, 2012 its commercial lease financing held-for-investment loans totaled $6.3 million. The Company offers warehouse lines of credit to other mortgage lenders. As of December 31, 2012, there were 311 warehouse lines of credit to other mortgage lenders with an average size of $7.5 million.
Mortgage Banking
The Company�� Mortgage Banking segment originates, acquires, sells and services one-to-four family residential first mortgage loans. Mortgage loans are originated through home lending centers, national call centers, the Internet, unaffiliated banks and mortgage brokerage companies. Also, the Mortgage Banking segment services mortgage loans for others and sells MSRs into the secondary market.
In a home lending center transaction, loans are originated through a network of its loan origination centers, as well as referrals from its Banking segment and the national call center. At December 31, 2012, the Company maintained 31 loan origination centers. In a broker transaction, an unaffiliated bank or mortgage brokerage company completes the loan paperwork, but the loans are underwritten on a loan-level basis to its underwriting standards and it supplies the funding for the loan at closing thereby becoming the lender of record. As of December 31, 2012, the Company had active broker relationships with over 1,700 banks, credit unions! , and mor! tgage brokerage companies. In a correspondent transaction, an unaffiliated bank or mortgage company completes the loan paperwork and also supplies the funding for the loan at closing. As of December 31, 2012, the Bank had active correspondent relationships with over 1,300 companies, including banks, credit unions, and mortgage companies.
Advisors' Opinion: - [By Jessica Alling]
Outside the Dow, insurer MBIA (NYSE: MBI ) is up 11.3% after settling a legal case with lender Flagstar Bancorp (NYSE: FBC ) over two mortgage-backed securities transactions. MBIA alleged that Flagstar misrepresented the securities, resulting in the insurer's payout of $165 million on the policies. Flagstar has agreed to pay MBIA $110 million to settle the case. This legal dispute is similar to the current battle between MBIA and Bank of America. The insurer recently lost its bid for a pretrial ruling on the case, driving the stock lower.
Top 10 Safest Companies To Own For 2014: Dolby Laboratories Inc (DLB)
Dolby Laboratories, Inc., incorporated in 1967, develops and delivers products and technologies that are used in the entertainment industry. Its audio technologies are used throughout the global entertainment industry. It is developing and marketing video technologies to improve the quality of video presentation. Its offerings include video products aimed at the cinema market, such as its digital cinema server, its Dolby three-dimensional (3D) Digital Cinema products, and its Dolby PRM-4200 Professional Reference Monitor. It offers products and services to content creators, such as studios, broadcasters, and downloadable content service providers to encode content using Dolby�� technologies. As of September 24, 2010, the Company sold its products and provide services in over 85 countries. In addition, it has licensed its technologies to CE manufacturers and to software vendors in 40 countries, which in turn distribute their products incorporating its technologies throughout the world.
The Company designs and manufactures video and audio products for the film production, cinema, and television broadcast industries. Distributed in over 60 countries, these products are used in content creation, distribution and playback to improve image and sound quality, provide surround sound, and increase the efficiency of sound storage and distribution. Its product sales are derived from sales of its digital 3D products, which provide 3D capabilities, as well as sales of digital cinema servers that load, store, decrypt, and decode encrypted digital film files for presentation on digital projectors in theaters. Revenue is also derived from sales of its traditional cinema processors, which movie theaters use to process film soundtracks, and from sales of broadcast products used to encode and distribute content to viewers. It also offers related digital cinema processors and media adapters to decode digital cinema soundtracks, and digital cinema accessories that allow exhibitors to integrate its digital ! cinema servers with their existing automation systems.
The Company offers a variety of services to support film production, television broadcast and music production. The Company enters into service agreements with motion picture studios or filmmakers to provide them with production services related to the preparation of a Dolby soundtrack, such as equipment calibration, mixing room alignment and equalization. Dolby provides other services, such as print quality control, professional film mastering services to prepare movies for digital release, and theatre system calibration for important screenings, such as premieres, film festivals, and press screenings. Its engineers also provide training, system design consultation and onsite technical expertise to cinema operators throughout the world to help them configure their screening rooms and equipment to ensure that movies are replayed with consistent high quality.
The Company�� technologies include dolby digital, dolby digital plus, dolby digital surround EX, dolby digital EX, advanced audio coding (AAC), HE AAC, dolby pulse, dolby trueHD, dolby E, dolby digital live, dolby pro logic II, dolby pro logic II(x), dolby pro logic IIz, dolby virtual speaker, dolby headphone, dolby mobile, dolby axon, PC entertainment experience (PCEE), dolby digital stereo creator, dolby digital 5.1 creator, dolby volume, dolby contrast, dolby vision and analog signal processing technologies. Its products include traditional cinema processors, digital cinema products, digital 3D products, digital media adapters, broadcast products and professional reference monitor.
Traditional cinema processors are used to read, decode and play back a film�� soundtrack and calibrate the sound system in a movie theater. Digital cinema products are used for digital cinema encoding, distribution and playback. Our digital cinema server is used to load, store, decrypt, decode and re-encrypt digital film files for presentation on a digital cinema project! or. We al! so provide products that encrypt, encode and package digital films, and digital cinema processors to decode digital cinema soundtracks. Digital 3D products deliver a 3D image with an existing digital cinema server and white screen, providing exhibitors a flexible 3D solution. Its Dolby 3D glasses feature high-quality multicoated lenses with a special curvature that delivers 3D images.
Digital media adapters are used to adapt existing analog cinema audio systems to the latest digital audio technologies. Broadcast products are used to encode, transmit and decode multiple channels of high-quality audio for Digital Television (DTV) and high-definition television (HDTV) program production and broadcast distribution and to measure the subjective loudness of audio content within broadcast programming. Professional reference monitor is a video monitor used during the production and post-production of cinematic and video content in situations, where grade one reference performance is required.
The Company competes with Audyssey Laboratories, DTS, Fraunhofer Institute for Integrated Circuits, Microsoft, Philips, RealNetworks, Sonic Solutions, Sony, SRS Labs, Thomson, Barco, Doremi, GDC, IMAX, MasterImage 3D, NEC, Panavision, QSC Audio Products, Qube Cinema, REAL D, Technicolor, Texas Instruments, USL, XpanD and DTS.
Advisors' Opinion: - [By Rich Duprey]
Enter Dolby Labs' (NYSE: DLB ) glasses-free technology, which could revolutionize or at least revitalize the�3-D TV industry.
In partnership with Philips (NYSE: PHG ) , the sound specialist is developing a suite of technologies that are used during production and in the TV sets themselves that allows viewers to see a picture in�3-D without having to wear glasses. Moreover, the technology works�on any 3-D TV, tablet, laptop, or smartphone, and can convert any 2-D display into an equally sharp 3-D display.
Top 10 Safest Companies To Own For 2014: CPFL Energia S.A.(CPL)
CPFL Energia S.A., through its subsidiaries, engages in the generation, distribution, and sale of electricity in Brazil. It generates electricity through hydroelectric, thermal, biomass, and wind power plants. The company also involves in the provision of energy commercialization, consultancy, and advisory services to agents in the energy sector; manufacture, commercialization, rental, and maintenance of electromechanical equipment; and provision of administrative services, as well as telephone answering services. It has an installed generating capacity of 2,309 MW. The company was founded in 1998 and is headquartered in Sao Paulo, Brazil.
Advisors' Opinion: - [By Jake L'Ecuyer]
Leading and Lagging Sectors
Utilities sector surged 0.26%, saw CPFL Energia SA (NYSE: CPL) as the top gainer. Among leading sector stocks, gains came from Consolidated Water Co (NASDAQ: CWCO), Companhia Paranaense de Energia (NYSE: ELP) and Public Service Enterprise Group (NYSE: PEG).
Top 10 Safest Companies To Own For 2014: BioTime Inc (BTX)
BioTime, Inc., incorporated on November 30, 1990, is a biotechnology company focused on the emerging field of regenerative medicine. Its commercial strategy is focused on its line of research products, such as ACTCellerate cell lines and associated ESpan culture media, HyStem hydrogels, human embryonic stem (hES) cell lines, and royalties from Hextend. Its focus is to provide regenerative therapies for age-related degenerative diseases. In January 2011, the Company acquired the assets of Cell Targeting, Inc. (CTI), a biotechnology company focused on methods of painting molecules on the surface of cells, which in turn causes the cells to adhere to particular tissues, such as those afflicted with disease. On March 21, 2011, the Company acquired Glycosan BioSystems, Inc. (Glycosan) through a merger of Glycosan with OrthoCyte Corporation (OrthoCyte). Through the merger, OrthoCyte acquired all of Glycosan�� assets, including Glycosan�� Hystem hydrogel product line. In March 2011, the Company entered into an agreement with XenneX, Inc., pursuant to which it organized LifeMap Sciences, Inc. (LifeMap), a subsidiary formed to advance the development and commercialization of its human embryonic stem (hES) cell data base. In August 2011, four hES cell lines (ESI-035, ESI-049, ESI-051 and ESI-053) developed by its subsidiary ES Cell International (ESI) were approved by the National Institutes of Health (NIH) for inclusion in the NIH Human Embryonic Stem Cell Registry. In May 2012, the Company acquired XenneX, Inc., through a merger of XenneX into LifeMap Sciences. In September 2012, the Company formed a wholly owned subsidiary, BioTime Acquisition Corporation. In October 2013, Geron Corporation announced the closing of the transaction to divest the Company's stem cell assets to Asterias Biotherapeutics, Inc., a subsidiary of BioTime, Inc.
HyStem is a biomaterial, which mimics the human extracellular matrix, which is the network of molecules surrounding cells in organs and tissues which is essent! ial to cellular function. Its HyStem hydrogels may have other applications when combined with the diverse and scalable cell types its scientists have isolated from hES cells. HyStem-Rx is a clinical grade formulation of HyStem-C, a biocompatible, implantable hyaluronan and collagen-based matrix for cell delivery in human clinical applications. Its subsidiary, OncoCyte Corporation, is developing PanC-Dx, a non-invasive blood-based cancer screening test designed to detect the presence of various human cancers, including cancers of the breast, lung, bladder, uterus, stomach, and colon, during routine check -ups. BioTime Asia, Limited (BioTime Asia) sells products for research use and may develop therapies to treat cancer and neurological and orthopedic diseases in Asia. OrthoCyte Corporation (OrthoCyte) is developing therapies to treat orthopedic disorders, diseases and injuries. ReCyte Therapeutics, Inc. (ReCyte Therapeutics) is developing therapies for age-related cardiovascular and blood disorders. Cell Cure Neurosciences Ltd. (Cell Cure Neurosciences), is a biotechnology company focused on developing stem cell-based therapies for retinal and other neurological disorders, including the development of retinal pigment epithelial (RPE) cells for the treatment of age-related macular degeneration. LifeMap Sciences, Inc. (LifeMap) is advancing the development and commercialization of our embryonic stem cell database and plans to make the database available for the marketing of research products and for use by stem cell researchers at pharmaceutical and biotechnology companies and other institutions via paid subscriptions or on a fee per use basis.
The Company�� blood plasma expander product, Hextend, is a physiologically balanced intravenous solution used in the treatment of hypovolemia, a condition caused by low blood volume, often from blood loss during surgery or injury. Hextend maintains circulatory system fluid volume and blood pressure, and keeps vital organs perfused during surgery and t! rauma car! e. Hextend is manufactured and distributed in the United States by Hospira, Inc., and in South Korea by CJ CheilJedang (CJ), under license from it.
Human Embryonic Stem Cell Lines for Research Use
Combined with the Company�� ACTCellerate technology, it derives of a range of markets human embryonic progenitor cells (hEPCs). ESI�� six current good manufacturing practices (cGMP) hES cell lines have been approved by the NIH for inclusion in the Human Embryonic Stem Cell Registry, which renders those cell lines eligible for use in federally funded research. The ESI hES cell lines are available for purchase through www.biotimeinc.com. It also markets hEPCs developed using ACTCellerate technology. Its hEPCs are also available for sale through www.biotimeinc.com. It derived the complete genome sequence of five of the ESI hES cell lines to facilitate the development of products derived from these cell lines. It has made these GMP-grade cell lines, along with certain documentation and complete genomic deoxyribonucleic acid (DNA) sequence information, available for sale.
The Company offers human stem cell products and technology that can be used by researchers at universities and at companies in the bioscience and biopharmaceutical industries. It has developed research and clinical grade hES cell lines, which it markets for both basic research and therapeutic product development. It also markets human embryonic progenitor cell (hEPCs) developed using ACTCellerate technology. These hEPCs are purified lineages of cells, which are intermediate in the developmental process between embryonic stem cells and fully differentiated cells. The ACTCellerate cell lines are also available for purchase through http://www.biotimeinc.com.
Human Embryonic Progenitor Cells
Through the Company�� subsidiary ReCyte Therapeutics, it had a license from Advanced Cell Technology, Inc. (ACT) to use ACTCellerate technology, and the rights to market more than 200 human c! ell types! made using that process. ACTCellerate allows the rapid isolation of hEPCs, which are cells that are intermediate in the developmental process between embryonic stem cells and fully differentiated cells.
Through an agreement with ReCyte Therapeutics, Millipore Corporation became a global distributor of ACTCellerate hEPC lines. In addition to the products, which it is co-marketing with Millipore, it offers 92 other ACTCellerate hEPC lines for purchase at www.biotimeinc.com. Through its subsidiary LifeMap, it provides online biomedical database services to increase awareness of molecular markers and diverse cell types comprising its ACTCellerate hEPC lines. It also focuses to market additional cell types manufactured with its PureStem technology. PureStem cell lines are produced by the exogenous expression of specific transcription factors, which regulate the differentiation of cell types from hES or induced pluripotent stem (iPS) cells. BioTime Asia has an agreement with Shanghai Genext Medical Technology Co., Ltd. to sell ACTCellerate hEPC lines and related ESpan growth media to the medical and biological research communities in China, Taiwan, Hong Kong, and Macau on an exclusive basis. The marketing agreement includes provisions for an initial stocking inventory and annual milestones to maintain exclusivity. The Company�� California Institute of Regenerative Medicine (CIRM)-funded research addresses the need for industrial scale production of purified therapeutic cells.
hES Cells Carrying Genetic Diseases
The Company focuses to add to its product line muscle progenitor cells produced from five hES cell lines carrying genes for Duchenne muscular dystrophy, Emery-Dreifuss muscular dystrophy, spinal muscular atrophy Type I, facioscapulohumeral muscular dystrophy 1A, and Becker muscular dystrophy. It obtained the diseased hES cell lines from Reproductive Genetics Institute (RGI).
ESpan Cell Growth Media
The Company is marketing a range of! cell-gro! wth media products called ESpan. These growth media are optimized for the growth of hEPC types. Cells need to be propagated in liquid media, in both the laboratory setting, where basic research on stem cells is performed, and in the commercial sector. Its ESpan products are marketed through Millipore and Genext.
ESpy Cell Lines
The Company focuses for development of ESpy cell lines. The ability of the ESpy cells to emit light will allow researchers to track the location and distribution of the cells in both in vitro and in vivo studies.
HyStem Hydrogel for Research and HyStem-Rx for Cell Delivery Medical Devices
HyStem is a patented biomaterial that mimics the ECM, the network of molecules surrounding cells in organs and tissues that is essential to cellular function. Its HyStem technology forms the foundation for stem cell delivery products in both the adult and embryonic stem cell marketplace, including products manufactured using its ACTCellerate technology. As an injectable product, HyStem-Rx may address need in cosmetic and reconstructive surgeries and other procedures by transplanting adipose derived cells or other adult stem cells. The transfer of cells in HyStem-Rx localizes the transplanted cells at the intended site and by providing a three-dimensional scaffold upon which cells can rebuild normal tissue. HyStem-Rx may support other emerging cell and tissue transplant therapies, such as those derived from hES and iPS cells, in addition to its potential application in the treatment of a range of conditions such as osteoarthritis, brain tumors, stroke, bone fracture, and wounds.
Advisors' Opinion: - [By Brian Pacampara]
Based on the aggregated intelligence of 180,000-plus investors participating in Motley Fool CAPS, the Fool's free investing community, biotechnology company BioTime (NYSEMKT: BTX ) has received the dreaded one-star ranking.
